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Pre-clinical studies have reported that fat mass reduction with 5-Amino-1MQ treatment is accompanied by relative preservation of lean mass , a body composition profile that distinguishes NNMT inhibition from caloric restriction, which typically reduces both fat and lean mass proportionally

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This leads to damage to tissue cells, including vascular ECs (Incalza et al., 2018), adipocytes (Furukawa et al., 2004), and pancreatic β-cells (Gerber and Rutter, 2017)