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The electron densities for the bound ligands were also reasonably well defined in most cases (Supplementary Figure S1), although the C-terminal residues of Met- and Leu-enkephalin were found to be flexible and the occupancy of endomorphin-2 had to be reduced to 0.8
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In neuromyelitis optica spectrum disorder (NMOSD), AQP4 is the main target of pathogenic IgG1 antibodies, inducing complement- and antibody-dependent cytotoxicity [286]
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