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This is common with many metabolic peptides and supplements—your body develops tolerance, and the initial benefits diminish

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While most skin substitutes are either medical devices regulated under the FD&C Act or products regulated solely under section 361 of the PHS Act, subparagraphs (H) and (I) of section 1847A(c)(6) of the Act only refer to biological products under section 351 of the PHS Act