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Rapid suppression of plasma testosterone levels and tumor growth in the Dunning rat model treated with degarelix, a new gonadotropin-releasing hormone antagonist
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Mechanistically, NNMT knockdown suppresses hepatic gluconeogenesis by downregulating key genes such as Pck1 (phosphoenolpyruvate carboxykinase 1) and G6pc (glucose-6-phosphatase catalytic subunit), leading to reduced glucose output in primary hepatocytes [24]
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