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Furthermore, an unpublished report suggests that extracellular mucin modulates the release of the Akkermansia protein secretome, which dysregulates calcium homeostasis, leading to the promotion of calcium uptake in the mitochondria of entero-endocrine cells, triggering the formation of reactive oxygen species and subsequent α-synuclein phosphorylation, aggregation, and deposition in vitro ( in vitro evaluation, it highlights previously unknown functions of distinct microbes in influencing the formation of pathogenic fibrils (Figure 2A)