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Six months of voluntary wheel running significantly downregulated the expression of Ferritin, HO-1, janus kinase 1 (JAK1), signal transducer and activator of transcription 3 (STAT3), DMT1, TFR, and hepcidin in the cerebral cortex of five familial Alzheimer’s disease (5×FAD) mice, reduced Aβ and IL-6 levels, inhibited Aβ plaque deposition and neuroinflammation, thereby improving neurological deficits in AD mice ( 2 max significantly downregulated the levels of TFR1, TF, DMT1, FTL, FTH, mitochondrial Ferritin, β-secretase, and APP in the cortical motor regions of aged amyloid precursor protein-C105 (APP-C105) mice, upregulated the expression of FPN1, Furin, and α-secretase, significantly reduced Fe 2+ , Fe 3+ , and total iron content, inhibited brain iron accumulation and Aβ plaque growth, thereby improving learning ability, memory, and cognitive function in aged APP-C105 mice ( G93A transgenic mice, significantly reduced the expression of FTL, FTH, Ferritin, TFR1, and APP, upregulated FPN1 expression, inhibited Aβ and iron accumulation in skeletal muscle, and improved neural function in the mice

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Naturopathic treatments often include one or more of the following: Acupuncture The use of acupuncture, diet and traditional botanical formulas comes from an Eastern philosophical and medical perspective for the treatment of diverse conditions

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