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ERT is also potentially limited by reaccumulation of Gb3 in podocytes after dose adjustment during the follow-up period and formation of neutralizing antidrug antibodies after infusion, which reduce the efficacy of ERT by increasing cellular Gb3 deposition and results in harmful clinical outcomes that include progressive loss of renal function 13,14

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Mechanism of Action in Research Contexts Modulation of intracellular signaling pathways Enhancement of growth factor sensitivity in research models Regulation of gene expression patterns Influence on mitochondrial ATP production and cellular energy regulation Support of enzymatic activation and inhibition pathway analysis Primary Research Applications Cellular Repair and Regeneration Studies: Investigating controlled cellular behavior and experimental tissue modeling under laboratory conditions