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Adult immersion test (AIT) Thirty unfed adults were allocated into 3 replicates ( n = 10/replicate) and immersed in 5 ml of the tested concentrations for 2 min according to Abdel-Ghany et al

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1 Introduction Migraine manifests as a chronic neurovascular disease characterized by unilateral or bilateral throbbing severe headaches, predominantly unilateral, recurring with symptoms such as nausea, vomiting, photophobia, and phonophobia that impair autonomic nervous system functions (Steiner and Stovner, 2023) many sufferers cannot perform normal or work activities