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(2021), Lancet 397(10286), PubMed 33894838 Statistiken aus der präklinischen Literatur Cagrilintide (Entwicklungscode AM833 ), long-acting Amylin-Analogon , 32 Aminosäuren, Molekulargewicht 3,795 kDa Entwickelt bei Novo Nordisk (Dänemark) als Teil des Kombinationsprogramms CagriSema (cagrilintide + semaglutide) Ziel: Amylin-Rezeptoren (AMY1, AMY2, AMY3) + sekundär Calcitonin-Rezeptor , verlängerte Halbwertszeit über einen C16-Fettsäurelinker Standarddosis in klinischen Studien: 0,16–4,5 mg/Woche subkutan (Phase 1b/2) Phase 2 (Enebo 2021, n=96): 17,1 % Reduktion des Körpergewichts mit CagriSema 2,4 mg + 2,4 mg über 20 Wochen vs
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