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The pathophysiological mechanisms, including inducing autoimmune responses, hormonal disorders, and exerting an effect on the possible thyroid-gut-microbiome-brain axis, have underpinned the role of GD as a crucial driver in the development of depression and depressive symptoms
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Fecal microbiota transplantation , in both clinical and preclinical settings, was reported to restore CD8+ T cell activity and reduce immunosuppressive IL-8-producing myeloid populations, confirming the causal role of microbiota composition in modulating ICIs efficacy [187]
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