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Individuals with Medical Conditions Consult a doctor before use if you: Have kidney disease Have asthma Are undergoing chemotherapy Take blood thinners or prescription medication Have a chronic medical condition Professional medical advice is always recommended before starting any new supplement routine

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Here is what has actually been tested in people, ranked from most to least studied: Chronic knee pain — the retrospective study with 12 patients receiving intra-articular injections Interstitial cystitis pain — a small pilot study exploring bladder-related chronic pain General safety and pharmacokinetics — a 2025 report on two healthy adults receiving IV doses up to 20 mg, with no adverse events reported Animal research covers a wider range of conditions, including tendon tears, ligament injuries, and muscle damage