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Studies are needed to address the effects of specific genetically modified mice with altered FOXO proteins as well as the impact of FOXO6 in neurodegenerative disorders due to the lack of studies on this protein in these disorders
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Acetylation spatial regulation An alternative strategy for controlling enzyme selectivity and activity is through spatial confinement, which enables acetylation to occur preferentially on proteins within specific compartments such as the nucleus, cytoplasm, mitochondria, and endoplasmic reticulum
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