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A structural study argues that for a given strand, both polymerase and ligase-dependent steps employ polymerase and ligase molecules that are present on the same arm of a short-range complex – an active arm (vs
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In Bullous Pemphigoid Antibody (usually IgG) found on the blister roof (epidermal side) In EBA (Collagen VII): Antibodies found on blister floor (dermal side) In Mucous Membrane Pemphigoid: Deposition can be to roof, floor, or mixed pattern depending on antigens targeted Roof - BP 180, 230, α6β4 integrin Floor - Laminin 332, Type VII collagen SERRATION PATTERN Looking at the serration pattern refines localization beyond what salt split skin shows
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