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In contrast, tumor-promoting immune cells consist mainly of Tregs, myeloid-derived suppressor cells (MDSCs), M2-type macrophages and N2-type neutrophils, which facilitate tumor progression by suppressing antitumor immune responses ( One study reported that tumors with elevated cholesterol metabolism are associated with an immunosuppressive microenvironment, characterized by an increased presence of Tregs and M2-type macrophages
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