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Reduced glutathione is typically present at much higher intracellular concentrations than cysteine and, given the toxicity of free cysteine, may represent the preferred ‘safe’ storage form of cysteine within the cell [52, 71]

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In this review, we summarize the current existing literatures on NADPH homeostasis, including its biological functions, regulatory mechanisms and the corresponding therapeutic interventions in human cancers, providing insights into therapeutic implications of targeting NADPH metabolism and the associated mechanism for cancer therapy