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Final thoughts Stopping GHK-Cu typically produces gradual benefit decline over 2-4 months without dramatic rebound effects or rapid reversal to pre-treatment baseline, with 30-40% of long-term users (6+ months treatment) maintaining 50-70% of peak improvements indefinitely while shorter-term users show greater regression toward baseline

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To restore endogenous testosterone, mainly aromatase inhibitors (AIs), selective estrogen receptor modulators (SERMs), and human chorionic gonadotropin (hCG) are used (Karavolos et al., 2015