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Nuclear factor B (NFκB) and its active role in inflammation, cancer cell survival, and progression has been widely reported, with the ability to bind to the promoter of many pro-inflammatory genes, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and tumor necrosis factor (TNF) (137)
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On the other hand, protein supplementation may help to maintain protein synthesis during chronic inflammatory states, in addition to improving the immune response (267), while creatine supplementation could prevent protein degradation (268, 269)
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