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Among interferon-stimulated genes, IFI44L promoter hypomethylation is exceptionally consistent and has emerged as a diagnostic biomarker across tissues (130)
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(ii) Karyopyknotic cells in the affected brain areas (0–4) (score 0 indicates no change), cerebral (NTP-7, Level 3), cerebellar cortex (NTP-7, Level 6), hippocampus, thalamus, and hypothalamus (NTP-7, Level 3) were analyzed as follows: a few karyopyknotic neuronal cells (≤20%) (score 1)
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