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The most significantly downregulated protein was Svs5 (seminal vesicle secretory protein 5) with a log 2 FC of −2.02 ( p = 0.011)
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In obese patients, acipimox can inhibit adipose tissue lipolysis by activating protein upregulated in macrophage by INF-γ (PUMA-G) (also known as the hydroxycarboxylic acid receptor 2 [HCA2] and GPR109a) receptors
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