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A prospective randomised double-blind trial comparing ondansetron versus prochlorperazine for the prevention of nausea and vomiting in patients receiving high-dose cisplatin chemotherapy

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and increases the serum testosterone concentration.99 Furthermore, the mechanism by which botanical formulations ameliorate impaired testosterone synthesis also involves upregulating the expression of testicular steroidogenic enzymes, including 3β-HSD, StAR, CYP17A1, and CYP11A1.100 In summary, botanical extracts, bioactive compounds, and formulated preparations derived from medicinal plants largely exhibit dual potential in alleviating testicular or Leydig cell oxidative damage and promoting testosterone synthesis, highlighting their clinical value for treating testosterone deficiency syndromes through antioxidant pathways ( Table 3 )