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Neurosteroids, including 5-dihydro-progesterone (5-DHP), allopregnanolone (ALLO), and their stereoisomers, such as progesterone, are synthesized directly by brain neurons (glutamatergic and GABAergic long-projection neurons) in the CNS (Maguire et al., 2005), as well as by pathological conditions caused by delayed or traumatic stress, such as anxiety, depression, and PTSD (Romeo et al., 1998