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Research from the National Institute of Health indicates that the condition involves an abnormal wound healing process: Primary Causes Penile trauma – The most widely accepted theory suggests that micro-injuries to the penis during sexual activity, sports, or accidents trigger abnormal wound healing Genetic predisposition – Family history plays a role, with some men having inherited tendencies toward abnormal connective tissue formation Autoimmune factors – The body’s immune system may mistakenly attack penile tissue, leading to inflammation and scarring Risk Factors According to recent studies, several factors increase the likelihood of developing Peyronie’s disease: Age – Most commonly affects men between 40-70 years old, with risk increasing with age Connective tissue disorders – Including Dupuytren’s contracture, which affects up to 20% of men with Peyronie’s disease Diabetes mellitus – Men with diabetes-associated ED have a 4-5 times higher risk Erectile dysfunction – Pre-existing ED may contribute to penile trauma during sexual activity Smoking and alcohol use – These factors may impair healing and increase inflammation Certain medications – Some drugs may affect connective tissue formation Diagnosis and When to See a Urologist Early diagnosis and treatment of Peyronie’s disease are crucial for optimal outcomes