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In line with this, IL-23 promotes osteosarcoma progression in our models as IL-23 deficient or WT mice treated with anti-IL-23 neutralizing antibody-suppressed tumor progression

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The hepcidin knockout model, which mimics systemic hepcidin deficiency, exhibits age-dependent iron deposition in both the RPE and neural retina, leading to subsequent photoreceptor loss, lipofuscin accumulation, and subretinal neovascularization by 18 months of age [38]