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The essence of this paradigm shift is the elevation of therapeutic goals from the singular task of “pathogen eradication” to the systems-level endeavor of “host homeostasis reconstruction.” Accordingly, strategy prioritization must transition from a hierarchy based on “technical complexity” to a tiered framework anchored by the dual benchmarks of “translational cost-effectiveness” and “evidence maturity.” Only by completing this cognitive leap—from strategy comparison to paradigm shift—can 3R nanotechnology truly transcend the conceptual constraints of conventional antibiotics and advance from proof of concept toward clinical practice

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