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And what is more, in preclinical stages of RA, a systemic subclinical proinflammatory milieu is already recognized [9, 25], with the identification of circulating autoantibodies until 18 years before the clinical manifestations of the disease, reinforcing the idea that the immune dysregulation in RA patients is triggered even before the disease is clinically manifested [9, 24]

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[DOI] [PubMed] [Google Scholar] 149.Liao L.Y., He Y.F., Li L., Meng H., Dong Y.M., Yi F., Xiao P.G